Taben Hale, Ph.D. (Senior Mentor - TWIN 2)
Professor, Basic Medical Sciences
Interim Chair, Department of Basic Medical Sciences
Professor, Clinical Translational Sciences
University of Arizona, College of Medicine – Phoenix
Dr. Taben M Hale is a Professor in the Department of Basic Medical Sciences at the University of Arizona, College of Medicine – Phoenix. She completed her undergraduate as well as PhD (Pharmacology & Toxicology) training at Queen’s University in Kingston, ON Canada. She then moved on to the Université de Montréal where she pursued a Postdoctoral fellowship. She joined the College of Medicine – Phoenix in 2008 as one of the founding faculty in the Department of Basic Medical Sciences where teaches pharmacology to 1st and 2nd year medical students.
Dr. Hale has a broad background in cardiovascular physiology and pharmacology with a focus on blood pressure control and hypertension-related target organ damage. Her research elucidates the mechanisms that underlie the pathological structural remodeling in hypertensive heart disease, to identify novel therapeutic strategies to attenuate and reverse these processes. In addition, she investigates mechanisms by which prenatal stress alters fetal development to increase the risk of hypertension and cardiovascular disease later in life.
UA College of Medicine - Phoenix Dr Hale's lab : https://www.youtube.com/watch?v=CezBmG-MGaU
Follow Dr Hale at @TMHalePhD
Publications
Madhavpeddi L, Hammond B, Carbone DL, Kang P, Handa RJ, Hale TM†. “In utero dexamethasone exposure sex-selectively dysregulates cardiovascular function in adult rats” American Journal of Physiology – Heart and Circulatory Physiology. 2022 Apr 1;322(4):H597-H606. PMID: 35179975.PMID:35179975
JA Sheng, SML Tan, TM Hale, RJ Handa. “Androgens and their role in regulating sex differences in the hypothalamic/pituitary/adrenal axis response and stress-related behaviors” Androgens: Clinical Research and Therapeutics. 2021 Dec 23;2(1):261-274. PMID: 35024695 PMCID: PMC8744007. PMID:35024695
JA Sheng, NJ Bales, SA Myers, M Roueinfar, TM Hale, RJ Handa. “The hypothalamic-pituitary-adrenal axis: development, programming actions of hormones, and maternal-fetal interactions”. Frontiers in Behavioral Neuroscience 2021 Jan 13;14:601939 PMID: 33519393
Goldstein JM, Hale T, Foster SL, Tobet SA, Handa RJ. Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2019; 44(1):59-70 PMID: 30030541
Der Sarkissian S, Tea BS, Touyz RM, Deblois D, Hale TM (2013) Role of angiotensin II type 2 receptor during regression of cardiac hypertrophy in spontaneously hypertensive rats. Journal of the American Society of Hypertension (2):118-27. PMID: 23414835
Biwer LA, Broderick TL, Xu H, Carroll C, Hale TM. Protection against L-NAME-induced reduction in cardiac output persists even after cessation of angiotensin-converting enzyme inhibitor treatment. Acta Physiol (Oxf). 2013 Jan;207(1):156-65. PMID: 22834875
Biwer LA, D'souza KM, Abidali A, Tu D, Siniard AL, DeBoth M, Huentelman M, Hale TM. Time course of cardiac inflammation during nitric oxide synthase inhibition in SHR: impact of prior transient ACE inhibition. Hypertens Res. 2016 Jan;39(1):8-18 PMID: 26490086
D'Souza KM, Biwer LA, Madhavpeddi L, Ramaiah P, Shahid W, Hale TM. Persistent change in cardiac fibroblast physiology after transient ACE inhibition. Am J Physiol Heart Circ Physiol. 2015 Oct;309(8):H1346-53. PMID: 26371174
AM Garvin, BS Khokhar, MP Czubryt, TM Hale. “RAS inhibition in resident fibroblast biology” Cellular Signalling 2021 Apr;80:109903 PMID:33370581
Jen Hartmark-Hill, Taben Hale, Amelia Gallitano. “Women physicians and promotion in academic medicine” New England Journal of Medicine 2021 Feb 18; 384;7:680.