Examples of Key Discoveries from ICON-✘ Collaborators:
1
Prenatal maternal immune dysregulation occurring during 2nd-3rd trimester (key period of brain sexual differentiation) is significantly associated with higher risk in women than men for major depression and comorbid CVD risk. (Goldstein et al., 2018; Gilman et al., 2016)
2
Gene expression profiling identified sex differences in the maturation and immune reactivity of microglia, the immune cells of the brain. (Hanamsagar et al., 2017)
3
Microbial and viral infections may accelerate Alzheimer’s disease pathogenesis through accumulation of amyloid into fibrils. (Eimer et al., 2018)
4
Prenatal maternal immune dysregulation impacts sex differences in stress circuitry in the fetal brain that are retained across the lifespan with implications for sex differences in psychiatric disorders. (Goldstein et al., 2020)
5
ZBTB7C, which is involved in immunity regulation, shows sex-specific association with Alzheimer's disease in a family-based whole genome sequencing study. Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data (Dmitry Prokopenko et al. 2020)