Examples of Key Discoveries from ICON-✘ Collaborators:
1
In rats, fetal exposure to the glucocorticoid, dexamethasone, causes a predisposition to fatty liver disease, higher in females than males. (Carbone et al., 2012)
2
Insulin resistance-signaling pathway abnormalities in the brain in Alzheimer’s disease is associated with sex differences in cognitive decline. (Talbot et al., 2012)
3
In midlife abnormal insulin levels impact cognitive function later in life, in particular in women. This can be modified, e.g., through diet, exercise, weight management or other lifestyle changes, underscoring early intervention strategies. (Okereke et al., 2005) (Okereke et al., 2012)
4
Exposure to high levels of maternal androgens during prenatal development are associated with increased risk for metabolic syndrome and CVD in female vs. male offspring 40 years later. (Huang and Goldstein, 2018)
5
Genetic variants in the folate metabolic pathway contribute to cognitive deficits in neurodevelopmental disorders. (Roffman et al., 2013)