Stuart Tobet, Ph.D.

Professor & Director of the Department of Biomedical Sciences, School of Biomedical Engineering, Colorado State University (CSU)

Head of ICON-✘ Basic Science, Mass General Hospital

Affiliate Scientist, Department of Psychiatry, Mass General Hospital

Stuart A. Tobet, Ph.D., is Professor of Biomedical Sciences and Director of the CSU School of Biomedical Engineering. As Director of the CSU School of Biomedical Engineering that extends across 4 colleges and more than a dozen departments, his roles are to oversee a graduate training program and to promote interdisciplinary research at multiple levels in the university. He also serves on the University Graduate Education Council that provides him extensive input and understanding to a diverse universe of graduate student experiences. His laboratory studies how multiple signals affect migration and cell position that contribute to sex differences in structure or function in the developing nervous system and more recently in the gastrointestinal tract & Lungs. Live video microscopy studies in his laboratory provided the first direct evidence of sex differences and hormone influences on neuronal migration.

Most recently his lab established an ex vivo intestinal slice model that allows the study of neuroimmune and microbiome mechanisms in intestinal slices maintained ex vivo for several days. This recent work that for mouse models includes the enteric nervous system makes it possible to address peripheral issues downstream of autonomic dysregulation.

Education

  • Ph.D. in Neural and Endocrine Regulation (1985) - MIT, Cambridge, MA.. “Sexual dimorphism in the preoptic/anterior hypothalamic area of ferrets: Hormonal determinants and functional correlates."

  • MIT S.M. in Neural and Endocrine Regulation (1982) - MIT, Cambridge, MA. ". “Aromatization, catecholamines and sexual differentiation of the rat brain.”

  • Tulane University B.S. in Physiological Psychology (1978) - New Orleans, LA.

Read more about Dr. Tobet: http://csu-cvmbs.colostate.edu/academics/bms/Pages/stuart-tobet.aspx

Publications

Tobet SA, Fox TO. Sex- and hormone-dependent antigen immunoreactivity in developing rat hypothalamus. Proc Natl Acad Sci U S A. 1989 Jan;86(1):382-6. DOI: 10.1073/pnas.86.1.382. PMID: 2911582

Henderson RG, Brown AE, and Tobet SA: Sex differences in cell migration in the preoptic area/anterior hypothalamus of mice. J. Neurobiol., 41:252-266 (1999). PMID: 10512982

Bless EP, Walker HJ, Yu KW, Knoll JG, Moenter SM, Schwarting GA, Tobet SA: Live view of gonadotropin-releasing hormone containing neuron migration. Endocrinology, 146:463-468 (2005). PMID: 15486219

Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease. Goldstein JM, Handa RJ, Tobet SA. Front Neuroendocrinol. 2014 Jan;35(1):140-58. doi 10.1016/j.yfrne.2013.12.001. Epub 2013 Dec 16. PMID: 24355523 PMID: 24355523

Stratton MS, Staros M, Budefeld T, Searcy BT, Nash C, Eitel C, Carbone D, Handa RJ, Majdic G, Tobet SA. Embryonic GABA(B) receptor blockade alters cell migration, adult hypothalamic structure, and anxiety- and depression-like behaviors sex specifically in mice. PLoS One. 2014 Aug 27;9(8):e106015. doi: 10.1371/journal.pone.0106015. eCollection 2014.PMID: 25162235 PMID: 25162235

Schwerdtfeger LA, Tobet SA. Sex differences in anatomic plasticity of gut neuronal-mast cell interactions. Physiol Rep. 2021 Oct;9(19):e15066. doi: 10.14814/phy2.15066.PMID: 34605201 PMID: 34605201

JH