Jill M. Goldstein, Ph.D, M.P.H.

Founder & Executive Director ICON-✘

Professor of Psychiatry & Medicine, Harvard Medical School

Helen T. Moerschner Endowed MGH Research Institute Chair in Women’s Health

Department of Psychiatry

**Massachusetts General Hospital**

Jill M. Goldstein, M.P.H., Ph.D. is Professor of Psychiatry and Medicine, Harvard Medical School, Founder and Executive Director of the Innovation Center on Sex Differences in Medicine at Massachusetts General Hospital (MGH), and the Helen T. Moerschner Endowed MGH Research Institute Chair in Women’s Health. She is a clinical neuroscientist and expert in sex differences in health and diseases associated with the central nervous system, in particular, depression, its comorbidity with CVD, and risk for Alzheimer’s disease (AD).

She leads the interdisciplinary research program (NIH-funded for >30 years) Clinical Neuroscience Laboratory of Sex Differences in the Brain (cnl-sd.mgh.harvard.edu). She has received numerous awards, served on scientific review boards, and participated in strategic planning for NIMH, NIH ORWH, and the Institute of Medicine. She has spent her career at Harvard training the next generation of women and men in women’s health and sex differences in medicine, including leading an ORWH Harvard K12 training program on building interdisciplinary careers in women’s health.

In 2018, Dr. Goldstein launched the Innovation Center on Sex Differences in Medicine (ICON-✘) at Massachusetts General Hospital, leading a group of experts across departments and disciplines and in collaboration with sister institutions and the Mass General Research Institute. ICON-✘’s mission is to leverage fundamental discoveries “from cells to society” about sex differences in the brain and body in order to develop sex-selective diagnostics and therapeutics and target them early for intervention and prevention. In 2020, the National Institutes of Health designated ICON-✘ an NIH Specialized Center of Research Excellence (SCORE) for Sex Differences in Medicine, one of only 11 in the country.

More information on the MGH Clinical Neuroscience Laboratory of Sex Differences in the Brain

Follow Dr Goldstein on Twitter @JillMGoldstein

Publications

Makris N, Swaab DF, van der Kouwe A, Abbs B, Boriel D, Handa R, Tobet S, Goldstein JM. Volumetric Parcellation Methodology of the Human Hypothalamus in Neuroimaging: Normative Data and Sex Differences. NeuroImage. 2013 April 1 (69):1-10. PMID: 23247186.

Goldstein, JM, Langer, A., Lesser, J. Sex Differences in disorders of the heart and brain: A global crisis of multimorbidity and novel opportunity, JAMA Psychiatry Viewpoint, 2020. PMID: 32639554.

Konishi K., Cherkerzian S., Aroner S., Jacobs EG., Rentz, D., Remington A., Aizley, H., Hornig M., Klibanski A., Goldstein JM. Impact of BDNF and sex on maintaining intact memory function in early midlife. Neurobiology of Aging. 2019 doi.org/10.1016/j.neurobiolaging.2019.12.014. PMID: 31948671.

Garcia RG, Mareckova K, Holsen LM, Whitfield-Gabrieli S, Napadow V, Barbieri R, Goldstein JM. Impact of sex and depressed mood on the central regulation of cardiac autonomic function. Neuropsychopharmacology. 2020; 45(8): 1280-1288. doi: 10.1038/s41386-020-0651-x. PMID: 32152473.

Goldstein JM, Cohen JE, Mareckova K, Holsen L, Whitfield-Gabrieli S, Gilman SE, Buka SL, Hornig, M. Impact of prenatal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later. Proc Natl Acad Sci USA. 2021;118(15):e2014464118. doi:10.1073/pnas.2014464118 PMID: 33876747