Lydia Shook, MD
Maternal-Fetal Medicine specialist in the Department of Obstetrics and Gynecology
Investigator in the Vincent Center for Reproductive Biology
Massachusetts General Hospital
Dr Shook received her undergraduate and medical degrees from Yale University in New Haven, Connecticut, and completed residency in Obstetrics and Gynecology at Yale-New Haven Hospital. She completed the Maternal-Fetal Medicine fellowship at Massachusetts General Hospital in 2021, during which time she joined the Edlow lab as a Vincent Research Fellow to explore how maternal exposures and disease states, such as obesity, might affect fetal development through placental inflammation and immune activation. She was awarded the BWH/MGH NICHD WRHR (Women’s Reproductive Health Research) Faculty Career Development Award to support her work with the Edlow Lab investigating the impact of maternal SARS-CoV-2 infection and COVID-19 vaccination in pregnancy.
Twitter: @LydiaShook10
Publications
Major Research Interests: Infections in Pregnancy (SARS-CoV-2 infection), Fetal brain and placental programming
Edlow AG, Castro VM, Shook LL, Kaimal AJ, Perlis RH. Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy. JAMA Netw Open. 2022 Jun 1;5(6):e2215787. doi: 10.1001/jamanetworkopen.2022.15787.PMID: 35679048 PMID: 33351086
Shook LL, Edlow AG. A blood test to predict complications of pregnancy. Nature. 2022 Jan;601(7893):319-320. doi: 10.1038/d41586-021-03801-y.PMID: 34987208 No abstract available. PMID: 34987208
Kislal S, Shook LL, Edlow AG. Perinatal exposure to maternal obesity: Lasting cardiometabolic impact on offspring. Prenat Diagn. 2020 Aug;40(9):1109-1125. doi: 10.1002/pd.5784. Epub 2020 Aug 5.PMID: 32643194. PMID: 32643194
Shook LL, Kislal S, Edlow AG. Fetal brain and placental programming in maternal obesity: A review of human and animal model studies. Prenat Diagn. 2020 Aug;40(9):1126-1137. doi: 10.1002/pd.5724. Epub 2020 May 17.PMID: 32362000. PMID: 32362000
Bordt EA, Shook LL, Atyeo C, Pullen KM, De Guzman RM, Meinsohn MC, Chauvin M, Fischinger S, Yockey LJ, James K, Lima R, Yonker LM, Fasano A, Brigida S, Bebell LM, Roberts DJ, Pépin D, Huh JR, Bilbo SD, Li JZ, Kaimal A, Schust D, Gray KJ, Lauffenburger D, Alter G, Edlow AG. Sexually dimorphic placental responses to maternal SARS-CoV-2 infection. bioRxiv. 2021 Mar 29:2021.03.29.437516. doi: 10.1101/2021.03.29.437516. Preprint.PMID: 33821279. PMID: 33821279
Bordt EA, Shook LL, Atyeo C, Pullen KM, De Guzman RM, Meinsohn MC, Chauvin M, Fischinger S, Yockey LJ, James K, Lima R, Yonker LM, Fasano A, Brigida S, Bebell LM, Roberts DJ, Pépin D, Huh JR, Bilbo SD, Li JZ, Kaimal A, Schust DJ, Gray KJ, Lauffenburger D, Alter G, Edlow AG. Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses. Sci Transl Med. 2021 Oct 27;13(617):eabi7428. doi: 10.1126/scitranslmed.abi7428. Epub 2021 Oct 27.PMID: 34664987. PMID: 34664987
Shook LL, Bordt EA, Meinsohn MC, Pepin D, De Guzman RM, Brigida S, Yockey LJ, James KE, Sullivan MW, Bebell LM, Roberts DJ, Kaimal AJ, Li JZ, Schust D, Gray KJ, Edlow AG. Placental Expression of ACE2 and TMPRSS2 in Maternal Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Are Placental Defenses Mediated by Fetal Sex? J Infect Dis. 2021 Dec 8;224(Suppl 6):S647-S659. doi: 10.1093/infdis/jiab335.PMID: 34293137. PMID: 34293137
Gray KJ, Bordt EA, Atyeo C, Deriso E, Akinwunmi B, Young N, Baez AM, Shook LL, Cvrk D, James K, De Guzman R, Brigida S, Diouf K, Goldfarb I, Bebell LM, Yonker LM, Fasano A, Rabi SA, Elovitz MA, Alter G, Edlow AG. Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study. Am J Obstet Gynecol. 2021 Sep;225(3):303.e1-303.e17. doi: 10.1016/j.ajog.2021.03.023. Epub 2021 Mar 26.PMID: 33775692. PMID: 33775692
Edlow AG, Li JZ, Collier AY, Atyeo C, James KE, Boatin AA, Gray KJ, Bordt EA, Shook LL, Yonker LM, Fasano A, Diouf K, Croul N, Devane S, Yockey LJ, Lima R, Shui J, Matute JD, Lerou PH, Akinwunmi BO, Schmidt A, Feldman J, Hauser BM, Caradonna TM, De la Flor D, D'Avino P, Regan J, Corry H, Coxen K, Fajnzylber J, Pepin D, Seaman MS, Barouch DH, Walker BD, Yu XG, Kaimal AJ, Roberts DJ, Alter G. Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic. JAMA Netw Open. 2020 Dec 1;3(12):e2030455. doi: 10.1001/jamanetworkopen.2020.30455.PMID: 33351086 PMID: 33351086