Dmitry Prokopenko, Ph.D

Instructor in Neurology, Harvard Medical School

McCance Center for Brain Health Faculty Member, Genetics and Aging Research Unit

Massachusetts General Hospital

Dr Prokopenko is an experienced statistical geneticist with over ten years of experience in large-scale GWAS, NGS analyses and method development for such analyses. Current focus is Alzheimer’s disease genetics and statistical and computational problems posed by large-scale whole genome sequencing and other -omics data. This includes family-based association studies, rare variant studies, population structure, gene-by-environment and gene-by-gene interaction studies.

In Recent news: A new groundbreaking study, led by Mass General scientists, identifies 13 gene mutations that can provide important clues for restoring communication in the brain. (Article)

Publications

Major Research Interests: Biostatistics; genetics of Alzheimer's disease; whole genome sequence data 

Prokopenko D, Morgan SL, Mullin K, Hofmann O, Chapman B, Kirchner R; Alzheimer's Disease Neuroimaging Initiative (ADNI), Amberkar S, Wohlers I, Lange C, Hide W, Bertram L, Tanzi RE. Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development. Alzheimers Dement. 2021 Sep;17(9):1509-1527. doi: 10.1002/alz.12319. Epub 2021 Apr 2. PMID: 33797837
PMID: 33797837

Prokopenko D, Morgan SL, Mullin K, Hofmann O, Chapman B, Kirchner R, Amberkar S, Wohlers I, Lange C, Hide W, Bertram L, Tanzi RE. medRxiv. Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development. 2020 Nov 4:2020.11.03.20225540. doi: 10.1101/2020.11.03.20225540. Preprint. PMID: 33173892. PMID: 33173892

Lee S, Prokopenko D, Kelly RS, Lutz S, Ann Lasky-Su J, Cho MH, Laurie C, Celedón JC, Lange C, Weiss ST, Hecker J, DeMeo DL. Zinc finger protein 33B demonstrates sex-interaction with atopy-related markers in childhood asthma.Eur Respir J. 2022 Aug 11:2200479. doi: 10.1183/13993003.00479-2022. Online ahead of print. PMID: 35953101 PMID: 35953101

Dmitry Prokopenko, Julian Hecker, Rory Kirchner, Brad A. Chapman, Oliver Hoffman, Kristina Mullin, Winston Hide, Lars Bertram, Nan Laird, Dawn L. DeMeo, Christoph Lange & Rudolph E. Tanzi.Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data. Sci Rep. 2020 Mar 19;10(1):5029. PMCID: PMC7081222. PMCID: 32193444