Karen Miller, MD

Clinician at the Neuroendocrine Clinical Center

Chief of the Neuroendocrine Unit at the Massachusetts General Hospital

Professor of Medicine at Harvard Medical School

Massachusetts General Hospital

Dr Miller is an NIH-funded clinical researcher who studies the neuroendocrine regulation of body composition and brain function, with a focus on hormone deficiency and excess states, including growth hormone and androgens, on body composition and brain function.  Awards in recognition of her work have included The Endocrine Society International Award for Excellence in Published Clinical Research in The Journal of Clinical Endocrinology and Metabolism in 2006.  She is the author of more than 100 peer-reviewed publications and has served on the editorial board of the Journal of Clinical Endocrinology and Metabolism. Her research interests include hypopituitarism, acromegaly, androgen deficiency and replacement therapy in women and growth hormone deficiency and replacement therapy. ​ Major research interest: neuroendocrine regulation of body composition and brain function, metabolism, psychiatric & endocrine diseases, pituitary tumors.

Publications

Kimball A, Colling C, Haines MS, Meenaghan E, Eddy KT, Misra M, Miller KK.Dehydroepiandrosterone sulfate levels predict weight gain in women with anorexia nervosa.Int J Eat Disord. 2022 Aug;55(8):1100-1107. doi: 10.1002/eat.23767. Epub 2022 Jul 2.PMID: 35779065. PMID: 35779065

Singhal V, Bose A, Slattery M, Haines MS, Goldstein MA, Gupta N, Brigham KS, Ebrahimi S, Javaras KN, Bouxsein ML, Eddy KT, Miller KK, Schoenfeld D, Klibanski A, Misra M. Effect of Transdermal Estradiol and Insulin-like Growth Factor-1 on Bone Endpoints of Young Women With Anorexia Nervosa. J Clin Endocrinol Metab. 2021 Jun 16;106(7):2021-2035. doi: 10.1210/clinem/dgab145.PMID: 33693703 PMID: 35779065

Dichtel LE, Carpenter LL, Nyer M, Mischoulon D, Kimball A, Deckersbach T, Dougherty DD, Schoenfeld DA, Fisher L, Cusin C, Dording C, Trinh NH, Pedrelli P, Yeung A, Farabaugh A, Papakostas GI, Chang T, Shapero BG, Chen J, Cassano P, Hahn EM, Rao EM, Brady RO Jr, Singh RJ, Tyrka AR, Price LH, Fava M, Miller KK. Low-Dose Testosterone Augmentation for Antidepressant-Resistant Major Depressive Disorder in Women: An 8-Week Randomized Placebo-Controlled Study. Am J Psychiatry. 2020 Oct 1;177(10):965-973. doi: 10.1176/appi.ajp.2020.19080844. Epub 2020 Jul 14.PMID: 32660299 
PMID: 32660299

Dichtel LE, Nyer M, Dording C, Fisher LB, Cusin C, Shapero BG, Pedrelli P, Kimball AS, Rao EM, Mischoulon D, Fava M, Miller KK. Effects of Open-Label, Adjunctive Ganaxolone on Persistent Depression Despite Adequate Antidepressant Treatment in Postmenopausal Women: A Pilot Study. J Clin Psychiatry. 2020 Jun 9;81(4):19m12887. doi: 10.4088/JCP.19m12887.PMID: 32558402. PMID: 32558402

Schorr M, Dichtel LE, Gerweck AV, Valera RD, Torriani M, Miller KK, Bredella MA.Biol Sex Differ. 2018 Jun 27;9(1):28. doi: 10.1186/s13293-018-0189-3. Sex differences in body composition and association with cardiometabolic risk. PMID: 29950175. PMID: 29950175

Dichtel LE, Lawson EA, Schorr M, Meenaghan E, Paskal ML, Eddy KT, Pinna G, Nelson M, Rasmusson AM, Klibanski A, Miller KK. Neuroactive Steroids and Affective Symptoms in Women Across the Weight Spectrum.Neuropsychopharmacology. 2018 May;43(6):1436-1444. doi: 10.1038/npp.2017.269. Epub 2017 Nov 1.PMID: 29090684. PMID: 29090684