David Mischoulon, M.D., Ph.D.
Director, Depression Clinical and Research Program
Dr. David Mischoulon graduated in 1994 from the combined MD-PhD program at Boston University School of Medicine. He earned a PhD in biochemistry during this time, and authored several original papers in the area of liver biochemistry. He completed an internship in General Medicine at Carney Hospital in 1995. He then entered the Massachusetts General Hospital (MGH) Adult Psychiatry Residency Training Program, from which he graduated in 1998, after serving as Chief Resident in Psychopharmacology. Dr. Mischoulon is the Joyce R. Tedlow Professor of Psychiatry at Harvard Medical School, and Director of the Depression Clinical and Research Program (DCRP) of the MGH. Dr. Mischoulon’s research has focused on various areas of depression, including complementary and alternative medicine. He is also an accredited medical acupuncturist and has carried out studies of acupuncture as a treatment for depression. He has received two NARSAD Young Investigator awards, a K-23 award from NCCAM, an R01 grant from the NIH to study omega-3 fatty acids for depression, and recently a UG3 from NCCIH to continue his work on omega-3 fatty acids for depression. Dr. Mischoulon has mentored many research fellows and junior faculty, including investigators from Europe, Asia, and Australia, who have gone on to obtain independent funding as principal investigators.
Dr. Mischoulon has authored or co-authored more than 250 original articles, review articles, and book chapters. He has co-edited a textbook on natural medications for psychiatric disorders, and more recently an MGH guide to treatments of depression. He has been an invited speaker at various sites around the country and internationally, and has won several awards, including an appointment as a Distinguished Fellow of the Massachusetts Psychiatric Society and the American Psychiatric Association. In addition to his research activities, Dr. Mischoulon has been an active teacher in the MGH Department of Psychiatry’s residency program and various continuing medical education programs. He serves as Director of Training in the MGH Clinical Trials Network and Institute (CTNI), where he educates research clinicians on the proper administration of diagnostic instruments in clinical trials. He also cares for patients through the DCRP clinical practice, and is regularly sought out for consultation regarding management of treatment-resistant depression and use of complementary therapies for psychiatric disorders.
Publications
Ionescu DF, Swee MB, Pavone KJ, Taylor N, Akeju O, Baer L, Nyer M, Cassano P, Mischoulon D, Alpert JE, Brown EN, Nock MK, Fava M, Cusin C. Rapid and Sustained Reductions in Current Suicidal Ideation Following Repeated Doses of Intravenous Ketamine: Secondary Analysis of an Open-Label Study. J Clin Psychiatry. 2016 Jun;77(6):e719-25. doi: 10.4088/JCP.15m10056.
Nyer M, Gerbarg PL, Silveri MM, Johnston J, Scott TM, Nauphal M, Owen L, Nielsen GH, Mischoulon D, Brown RP, Fava M, Streeter CC. A randomized controlled dosing study of Iyengar yoga and coherent breathing for the treatment of major depressive disorder: Impact on suicidal ideation and safety findings. Complement Ther Med. 2018 Apr;37:136-142. doi: 10.1016/j.ctim.2018.02.006. Epub 2018 Feb 23
Pedrelli P, MacPherson L, Khan AJ, Shapero BG, Fisher LB, Nyer M, Cassano P, Parnarouskis L, Farabaugh A, Fava M, Silveri MM. Sex Differences in the Association between Heavy Drinking and Behavioral Distress Tolerance and Emotional Reactivity Among Non-Depressed College Students. Alcohol Alcohol. 2018 Nov 1;53(6):674-681. doi: 10.1093/alcalc/agy045.
Rapaport MH, Nierenberg AA, Schettler PJ, Kinkead B, Cardoos A, Walker R, Mischoulon D. Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study. Mol Psychiatry 2016 Jan;21(1):71-79. doi: 10.1038/mp.2015.22.
Yeung AS, Feng R, Kim DJH, Wayne PM, Yeh GY, Baer L, Lee OE, Denninger JW, Benson H, Fricchione GL, Alpert J, Fava M. A Pilot, Randomized Controlled Study of Tai Chi With Passive and Active Controls in the Treatment of Depressed Chinese Americans. J Clin Psychiatry. 2017 May;78(5):e522-e528. doi: 10.4088/JCP.16m10772.